منابع مشابه
Immersive Escape-Route Scenario with Locomotion Devices
The simulation of damaged buildings is of great interest. Virtual-reality technologies allow us to experience such a situation. A main concern here is escaping from the building. To simulate this scenario, a model of the environment and an interface for locomotion are needed. Locomotion inside virtual buildings requires special input devices. This paper discusses several simulation methods for ...
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We studied the effect on viral growth of drugs targeting different virus functions using a computer simulation for the intracellular growth of bacteriophage T7. We found that drugs targeting components of negative-feedback loops gain effectiveness against mutant viruses that attenuate the drug-target interaction. The greater inhibition of such mutants than of the wild type suggests a drug desig...
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WHY IMMUNE ESCAPE IS IMPORTANT Knowledge of the molecular virology of the hepatitis viruses and the responses they elicit has emphasised the importance of host immunity in resolving infection and mediating liver damage. Many viruses cause cytolytic infections in which viral replication occurs at the expense of host cell viability. However this is a shortsighted strategy for the virus as it prov...
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Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4(+) T cells. Due to these protective functions during immune responses, several pathogens, including RNA and DNA viruses, have developed strategies to inhibit autophagosome generation or maturation. Interest...
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numbers (Pantaleo et al., 1994).The CTL responses peak Virus infections are normally controlled, and often elimias the viraemia starts to fall, and then the expanded T nated, by T lymphocyte responses. Antibody may also cell populations fade because of apoptosis. All of this contribute but is probably more important in prophylaxis happens before any neutralizing antibody is detectable against r...
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ژورنال
عنوان ژورنال: Science
سال: 2011
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.331.6020.988-b